首页|流感病毒抑制剂的研究进展

流感病毒抑制剂的研究进展

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流感病毒可引起季节性流感及流感大流行,严重危害人类健康.抗流感病毒药物在控制流感爆发及流行中发挥重要作用.然而,当前可使用的抗流感病毒药物种类过少,且流感病毒极易突变,耐药病毒株不断增长,因此开发可抑制耐药病毒株的新药,以及开发具有全新抗病毒机制的抗流感病毒药物十分必要.通过对靶向流感病毒成分的抗流感病毒药物的研究进展进行综述,重点介绍各靶点药物的种类、作用机制、耐药产生情况以及如何针对耐药靶点进行"老药改造"和新靶点药物的开发,同时也对抗流感病毒药物的未来发展进行讨论,以期为流感病毒感染的治疗及药物研发提供参考.
Advances in Influenza Virus Inhibitors
Influenza viruses cause seasonal influenza and influenza pandemics,which pose a serious threat to human health.Anti-influenza virus drugs are crucial in controlling the outbreak and spread of influenza.However,there are currently limited options of anti-influenza virus drugs in clinical practice.Additionally,influenza viruses are highly prone to mutation,leading to an increase in drug-resistant virus strains.Therefore,it is necessary to develop new drugs that can inhibit drug-resistant strains of the virus with novel antiviral mechanisms.This paper summarizes the research progress of anti-influenza virus drugs that target influenza virus components.It focuses on the types of drugs,their mechanisms of action,the occurrence of drug resistance,the transformation of old drugs and the development of new target drugs for drug resistance targets,as well as the future development of anti-influenza virus drugs,with the aim of providing some reference for therapy and the research and development of drugs against influenza virus infections.

influenza virusantiviral drugdrug-resistant virus strainnew target

黎敏科、杨博尧、吴益喜、徐畅、梁欢欢

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中山大学药学院(深圳),广东深圳 518107

流感病毒 抗病毒药物 耐药病毒株 新靶点

2024

药学进展
中国药科大学

药学进展

影响因子:0.624
ISSN:1001-5094
年,卷(期):2024.48(5)
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