Progress in the Structural Composition and Anti-tumor Effects of Peptide-Drug Conjugates
Peptide-drug conjugate(PDC)is an emerging targeted therapy,which covalently couples tumor-homing peptide and toxin by linker to improve its tumor penetration and targeting,improve its water solubility and pharmacokinetic properties,and reduce its systemic adverse reaction.This article reviews the research progress in this field by introducing the tumor-homing peptides,linkers,toxins commonly used in PDC drugs and the role of PDC drugs in tumor treatment,hoping to understand the research progress of PDC drugs more comprehensively and provide new possibilities for targeted therapy of tumors.
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