Organ fibrosis is characterized by excessive deposition of extracellular matrix(ECMs),and is an intermediate pathological process of chronic organ disease developing into cancer.At present,there is still no effective anti-fibrosis strategy.As pluripotent stem cells,mesenchymal stem cells(MSCs)can promote the repair of fibrotic tissues by differentiation,immune regulation,paracrine and homing;besides,their exosomes(MSC-Exos)as the delivery vectors show great potential in the treatment of organ fibrosis by transferring their active components to injured cells or targeting recipient cells,providing a new option for the treatment of organ fibrosis.Based on liver fibrosis,lung fibrosis,kidney fibrosis,cardiac fibrosis,skin fibrosis and pancreatic fibrosis,this paper summarizes the mechanisms and applications of MSCs and MSC-Exos in the treatment of organ fibrosis,in the hope of providing new insights to further develop stem-cell therapy for fibrosis.
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