Small interfering RNA(siRNA)is a new type of nucleic acid drug that plays its therapeutic roles through the RNA interference(RNAi)mechanism to target and silence the expression of target genes at the post-transcriptional level.As a precise,specific and efficient gene silencing therapy,siRNA has attracted much attention in the field of tumor-targeted therapy.Currently,several anti-tumor siRNA therapies have entered the clinical trial stage.This article summarizes the research progress of siRNA in tumor-targeted therapy in recent years,including the mechanism of action for siRNA,the recent development of anti-tumor siRNA drugs,and the optimization strategies for the in vivo delivery of siRNA drugs,aiming to provide new insights for the development and clinical application of anti-tumor siRNA drugs.
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