Research Progress of Soluble Guanylate Cyclase Stimulators and Activators
Soluble guanylate cyclase(sGC)is a cytosolic heterodimeric protein consisting of α and β subunits with heme groups located in the β subunit(heme binding domain,H-NOX domain).NO stimulates sGC activity by binding to Fe2+of the heme group,causing cGMP levels to rise.sGC can exist in two different forms,the natural heme-containing form as an endogenous NO receptor and the heme-free form that cannot bind NO.Stimulation of sGC with sGC stimulators or activators is a promising treatment strategy for cardiovascular and cardiac and renal diseases.This article briefly reviews the research progress of sGC stimulators and activators,aiming to provide some reference for the in-depth study of the regulatory mechanism of sGC and the development of sGC stimulators and activators.
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