中性粒细胞在药物性肝损伤中的作用研究进展
Progress of the Role of Neutrophils in Drug-Induced Liver Injury
文晴 1杨梦娇 1原玉柱 1赵永睿 1肖莉 2孙丽新1
作者信息
- 1. 中国药科大学多靶标天然药物全国重点实验室新药筛选与药效评价中心,江苏 南京 210009
- 2. 湖州师范学院生命科学学院,浙江 湖州 313000
- 折叠
摘要
在药物性肝损伤(DILI)的疾病发展过程中,被募集到肝脏中的中性粒细胞通过多种途径加重肝损伤的作用受到广泛关注.然而,中性粒细胞在不同种类药物导致的直接型、间接型、特异质型DILI中的作用机制不同,尚待进一步研究.综述中性粒细胞在DILI中发挥加重肝损伤作用以及中性粒细胞分别在乙酰氨基酚、雷公藤甲素和吡咯里西啶生物碱导致的直接型DILI,氟烷诱导的特异质型DILI,免疫检查点抑制剂引起的间接型DILI中的作用机制,为探究DILI的内在机制和治疗手段提供参考.
Abstract
In the disease progression of drug-induced liver injury(DILI),the role of neutrophils recruited into the liver in aggravating liver injury through various ways has attracted wide attention.However,the mechanisms underlying neutrophil-mediated liver injury in direct,indirect,and idiotypic DILI vary and require further investigation.This review aims to elucidate the role of neutrophils in exacerbating DILI-associated hepatic damage and explore their distinct actions in acetaminophen-,triptolide-,and pyrrolixidine alkaloid-induced direct DILI,halothane-induced idiotypic DILI,as well as immune checkpoint inhibitor-induced indirect DILI.These findings may offer valuable insights and strategies for understanding the pathogenesis and treatment of DILI.
关键词
中性粒细胞/药物性肝损伤/作用机制Key words
neutrophil/drug-induced liver injury/mechanism引用本文复制引用
出版年
2024
NETL
NSTL
万方数据