靶向肿瘤代谢酶小分子药物研究进展
Research Progress of Small Molecule Drugs Targeting Tumor Metabolic Enzymes
李顺尧 1冯磊 1张昕晨 1黄逸洋 1姚雪莹 1周璐1
作者信息
摘要
肿瘤细胞通过代谢重编程适应快速生长和分裂的需求,表现出与正常细胞不同的代谢特征,包括葡萄糖和氨基酸摄取失调、利用中心碳代谢支持生物合成、对氧化应激保护机制的依赖增加等.这些特征为靶向肿瘤代谢提供了潜在的治疗策略.综述糖、氨基酸、脂质及核酸代谢通路中的关键代谢酶及其靶向药物的研究进展,并展望了未来药物研发的新方向,以期为肿瘤治疗提供参考.
Abstract
Tumor cells adapt to the demands of rapid growth and division through metabolic reprogramming,exhibiting distinct metabolic characteristics compared to normal cells including dysregulated uptake of glucose and amino acids,utilization of central carbon metabolism to support biosynthesis,and increased reliance on mechanisms to protect against oxidative stress.These features present potential therapeutic strategies for targeting tumor metabolism.This review summarizes the research progress of key metabolic enzymes and their targeting drugs in the metabolic pathways of glucose,amino acids,lipids,and nucleic acids,and explores new directions in drug development,in the hope of providing more reference for tumor therapy.
关键词
肿瘤代谢/靶向代谢酶/小分子药物/临床在研药物Key words
tumor metabolism/targeting metabolic enzyme/small molecule drug/drug under clinical research引用本文复制引用
出版年
2024
NETL
NSTL
万方数据