Research Progress of Histamine H4 Receptor and Its Antagonists
Histamine H4 receptor(H4R),one of the subtypes of histamine receptors,is mainly expressed in the immune system and gastrointestinal tissues.The binding of histamine,the endogenous ligand of H4R,to H4R can lead to a significant increase of pro-inflammatory factors such as interleukin,and recruit immune cells to the inflammatory site,promoting the occurrence and development of a variety of inflammations and cancers.H4R can be used as a potential drug target for the treatment of inflammatory bowel disease,allergic rhinitis,atopic rhinitis,allergic asthma,rheumatoid arthritis,neuropathic inflammation,cancer and other diseases.Therefore,the study of novel selective H4R antagonists is of great significance for its drug development.This paper reviews the research progress of H4R and its antagonists in the hope of providing some reference for the research in this field.
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