全球超过10%的人口受到慢性肾病(chronic kidney disease,CKD)的威胁.大量研究证据表明,低水平的维生素D与CKD的进展和不良预后存在联系.随着研究的深入,维生素D及维生素D受体(vitamin D receptor,VDR)在CKD中的作用越来越受到关注.目前,提高CKD患者维生素D的水平或使用VDR激动剂成为CKD的治疗手段.对维生素D的合成与代谢,VDR的分布、功能与调控,维生素D与CKD之间的联系以及维生素D-VDR轴对CKD的保护机制4个方面进行综述,以期为CKD的疾病预防和治疗提供一定的理论依据及研究思路.
Role of Vitamin D-Vitamin D Receptor Axis in Chronic Kidney Disease
More than 10%of the global population are threatened by chronic kidney disease(CKD).Substantial research suggests that there is a link between low levels of vitamin D and the progression and adverse prognosis of CKD.With the deepening of research,the role of vitamin D and vitamin D receptor(VDR)in CKD has gained increasing attention.Recently,raising vitamin D levels or using VDR agonists in CKD patients has become a therapeutic approach for CKD.This article reviews the synthesis and metabolism of vitamin D,the distribution,function and regulation of VDR,the relationship between vitamin D and CKD,and the protective mechanism of vitamin D-VDR axis on CKD,in order to provide theoretical basis and research ideas for the prevention and treatment of CKD.
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