维生素D-维生素D受体轴在慢性肾病中的作用
Role of Vitamin D-Vitamin D Receptor Axis in Chronic Kidney Disease
孙娟 1崔雪扬 1王鹤霏 1江振洲 1黄鑫1
作者信息
- 1. 中国药科大学多靶标天然药物全国重点实验室新药筛选与药效评价中心,江苏 南京 210009
- 折叠
摘要
全球超过10%的人口受到慢性肾病(chronic kidney disease,CKD)的威胁.大量研究证据表明,低水平的维生素D与CKD的进展和不良预后存在联系.随着研究的深入,维生素D及维生素D受体(vitamin D receptor,VDR)在CKD中的作用越来越受到关注.目前,提高CKD患者维生素D的水平或使用VDR激动剂成为CKD的治疗手段.对维生素D的合成与代谢,VDR的分布、功能与调控,维生素D与CKD之间的联系以及维生素D-VDR轴对CKD的保护机制4个方面进行综述,以期为CKD的疾病预防和治疗提供一定的理论依据及研究思路.
Abstract
More than 10%of the global population are threatened by chronic kidney disease(CKD).Substantial research suggests that there is a link between low levels of vitamin D and the progression and adverse prognosis of CKD.With the deepening of research,the role of vitamin D and vitamin D receptor(VDR)in CKD has gained increasing attention.Recently,raising vitamin D levels or using VDR agonists in CKD patients has become a therapeutic approach for CKD.This article reviews the synthesis and metabolism of vitamin D,the distribution,function and regulation of VDR,the relationship between vitamin D and CKD,and the protective mechanism of vitamin D-VDR axis on CKD,in order to provide theoretical basis and research ideas for the prevention and treatment of CKD.
关键词
维生素D/维生素D受体/慢性肾病Key words
vitamin D/vitamin D receptor/chronic kidney disease引用本文复制引用
出版年
2024
NETL
NSTL
万方数据