胃癌组织中Her-2／neu基因的表达及其临床意义
Expression and Clinical Significance of Her-2/neu Gene in Gastric Carcinoma
刘春娜 1赵承梅 1马菲菲 1李卫东2
作者信息
- 1. 天津医学高等专科学校，天津市 300222
- 2. 天津医科大学总医院
- 折叠
摘要
目的：检测 Her-2/neu基因在胃癌组织中的蛋白表达，探讨其表达与胃癌患者临床病理指标及预后之间的关系。方法：收集手术切除胃癌患者临床病理资料，采用免疫组织化学SP法检测石蜡组织切片 Her-2/neu基因表达水平，分析与临床病理指标的关系及意义。结果：检测342例手术切除胃癌标本 Her-2/neu蛋白表达阳性90例（26.32％）。Her-2/neu基因表达在组织学类型、分化程度、浸润程度的组别间差异均无统计学意义（P＞0．05），而在肿瘤是否伴有淋巴结转移、远处转移和生存时间的组别间差异具有统计学意义（P＜0．05）。结论：Her-2/neu基因表达上调与淋巴结转移、远处转移及不良预后相关，可作为评估胃癌预后的重要参考指标。针对Her-2/neu基因靶点进行胃癌的分子靶向治疗有助于控制病程进展。
Abstract
Objective :To study the expression of Her-2/neu gene in gastric cancer tissues .The relationship between Her-2/neu gene expression and the clinicopathological indices ,the prognosis of gastric cancer patients was also studied in our research .Methods :342 gastric cancer tissues paraffin were detected with immunohistochemistry SP .To explore the relationship between the expression of Her-2/neu gene and clinical significance .Results:90 tissue samples were pos-itive in Her-2/neu gene expression ,and the positive ratio is 26 .32% .The expression of Her-2/neu gene in different groups of histological type ,histological grade and depth of invasion was no significant difference (P>0 .05) .However , the expression of Her-2/neu gene in different groups of lymph node metastasis ,distant metastasis and the survival time was statistically significant difference (P<0 .05) .Conclusion:The high expression of Her-2/neu gene is closely related with lymph node metastasis and distant metastasis in the progress of gastric cancer .The expression of Her-2/neu gene could be used as an important indicator to evaluate prognosis of gastric cancer .Her-2/neu gene could be used as a mo-lecular targeting in the treatment of gastric cancer .
关键词
胃癌/Her-2/neu基因/免疫组化/预后Key words
Gastric cancer/Her-2/neu gene/Immunohistochemistry/Prognosis引用本文复制引用
出版年
2014
NETL
NSTL
维普
万方数据