Study on the Correlation Between the Expression of Vascular Related Growth Factors in Advanced Colorectal Cancer and the Effect of Bevacizumab Combined with Chemotherapy
Objective:To investigate the relationship between the expression of angiogenesis-related factors in peripheral blood and the efficacy of bevacizumab combined with chemotherapy in patients with advanced colorectal cancer.Methods:66 patients with metastatic colorectal cancer who received bevacizumab combined with mFOLFOX-6 chemotherapy in our hospital from September 2021 to August 2023 were selected as study subjects.The sera of all patients were collected before the begin-ning of treatment,12 weeks and 24 weeks after treatment.The serum levels of vascular endothelial growth factor(VEGF),vascular endothelial growth factor receptor(VEGFR),human epidermal growth factor receptor-2(HER-2)and interleukin-8(IL-8)were measured by ELISA.The treatment results and adverse reactions of the two groups were observed and evaluated at 24 weeks of treatment,and the correlation between the above cytokines and treatment results was analyzed.Results:The to-tal effective rate after treatment was 37.88％.Both before and after treatment,the levels of VEGF,VEGFR and IL-8 in the effective group were significantly higher than those in the ineffective group,and the level of HER-2 in the ineffective group was higher than that in the effective group at 24 weeks.All cytokines in the effective group decreased significantly at 12 and 24 weeks of treatment.The HER-2 of the ineffective group had no significant difference compared with the baseline level at the 12th week of treatment,but decreased significantly at the 24th week of treatment.Conclusion:The baseline levels of VEGF,VEGFR and IL-8 may be related to the efficacy of bevacizumab combined with chemotherapy in the treatment of advanced colo-rectal cancer,and high levels of VEGF,VEGFR and IL-8 may indicate a better therapeutic effect.The change of serum HER-2 expression during bevacizumab combined chemotherapy is related to the treatment outcome,and the overexpression of HER-2 may indicate ineffective treatment and poor prognosis.
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