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愈肠颗粒的提取工艺研究

Extraction process optimization for Yuchang granules by orthogonal experiment

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目的 研究医院制剂愈肠颗粒的最优提取工艺.方法 以愈肠颗粒中的有效成分小檗碱、白术内酯Ⅰ的含量和浸膏得率为评价指标,采用正交试验法优选愈肠颗粒的最佳提取工艺.结果 通过正交试验的直观分析、方差分析及验证性实验,优选出其最佳提取工艺条件为:处方量药材加10倍量水提取;提取2次,每次1 h;提取液的醇沉浓度为70%.结论该工艺操作简单方便、稳定可行,可用作愈肠颗粒的优化提取方法.
Objective To investigate the extraction process of Yuchang granules .Methods The extraction process was optimized by orthogonal experiment based on the content of berberine ,atractylodes lactone Ⅰ and the extraction yield .Results Through the visual analysis of orthogonal experiment ,the analysis of variance and the verification experiments ,the optimum extraction process was obtained as follows :extracting 1 h for twice with 10 times water of medicinal herbs and the 70% ethanol depositing concentration .Conclusion This process is consistent and feasible .It is a simple and convenient method to extract Yuchang granules .

pharmacy preparationYuchang granulesorthogonal experimentextraction process

邵雪庆、唐晓萌、杨盟、卞俊、刘继勇

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第二军医大学附属长海医院药学部 ,上海 200433

解放军411医院药械科 ,上海 200081

医院制剂 愈肠颗粒 正交试验 提取工艺

上海市科委科技支撑项目上海市人才发展基金天然药物活性组分与药效国家重点实验室开放课题

16401901900201658SKLNMKF201612

2018

药学实践与服务
第二军医大学,中国药学会药事管理专业委员会

药学实践与服务

CSTPCD
影响因子:0.701
ISSN:2097-2024
年,卷(期):2018.36(1)
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