Adverse reaction analysis of drug-induced liver injury
Objective To analyze the adverse reaction reports(ADRs)of drug-induced liver injury in recent ten years,explore the characteristics and related rules of drug-induced liver injury,and provide reference for clinical safe drug use.Methods ADRs in our hospital from 2011 to 2021 which belonged to drug-induced liver injuries were collected,and Pareto analysis was carried on.Results In 259 ADR reports,the most common type of drug-induced liver injury was hepatocellular injury(37.84%).The age of drug-induced liver injury was mainly over 46 years,totaling 195(75.28%).Drugs were mainly distributed in cardiovascular system medicine(44.02%),anti-infective medicine(23.94%)and anti-tumor medicine(11.58%).Among the cardiovascular drugs,atorvastatin calcium 40mg and over 40mg were the highest proportion,with 53 cases(46.49%).The main anti-infectious drugs were cephalosporins(29.03%),carbapenem(19.35%),antifungal(17.74%)and quinolones(11.29%).Adverse reactions occurred within 6 days(69.88%),the duration of adverse reactions was 1-2 weeks(31.66%),and most patients were improved(47.88%)or cured(37.07%).Conclusion For middle-aged and elderly patients,when the application of cardiovascular system drugs,anti-infective drugs or anti-tumor drugs,it is necessary to monitor the liver function changes of patients for at least 6 days.If there are abnormalities,the drugs should be stopped or given treatment in time,to avoid the progress of drug-induced liver injury.
drug-induced liver injuryadverse drug reactionsPareto analysismedication safety
万方数据
维普
