首页|Synthesis and anti-inflammatory activity of 2-substituted-((N, N-disubstituted)-1, 3-benzoxazole)-5-carboxamides
Synthesis and anti-inflammatory activity of 2-substituted-((N, N-disubstituted)-1, 3-benzoxazole)-5-carboxamides
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A series of 2-substituted-((N, N-disubstituted)-1, 3-benzoxazole)-5-carboxamides derivatives were synthesized by the reaction of 2-substituted-5-carbomethoxy benzoxazole with different secondary amines.The newly synthesized compounds were characterized on the basis of spectral (FT-IR,1H NMR,MS) & elemental analysis.All these compounds were screened for anti-inflammatory activity using carrageenan induced rat paw edema method. All of these compounds exhibited significant activity.Among the tested compounds Ve, Vg,Vf and Va were considered to have potent anti-inflammatory activity and was comparable with standard.
benzoxazoleanti-inflammatory activitycarrageenan
Reena M、kiran G、Rajyalakshmi G、Venkateshwa Rao J、Sarangapani M
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Department of Pharmaceutical Chemistry, Talla Padmavati College of Pharmacy, Warangal 506001, India
Department of Pharmaceutical Chemistry, College of Pharmaceutical Sciences, Kakatiya University, Warangal 506009, India
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