Studies on the chemical constituents of the anti-osteoporotic part of Lepidium meyenii Walp.produced in Heqing
This study was designed to investigate the chemical constituents of the anti-osteoporotic part of Lepidium meyenii Walp.(maca) produced in Heqing,Yunnan.Seven compounds were isolated from the n-BuOH extract of maca using combination of column chromatographies on MCI resin,silica gel,C18 bonded silica gel,and Sephadex LH-20,followed by semi-preparative HPLC and recrystallization.The purified compounds were identified on the basis of their physicochemical properties and spectral data as macaolidine (1),tryptophan (2),daucosterol (3),(3S)-l,2,3,4-tetrahydro-β-carboline-3-carboxylicacid (4),chlorogenic acid (5),luteolin (6),and hyperoside (7).Compound 1 is a new phenylacetamide alkaloid,and compounds 4-7 were isolated from Lepidium meyenii for the first time.
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