Influenza virus causes serious threat to human life and health.Due to the inherent high variability of influenza virus,clinically resistant mutant strains of currently approved anti-influenza virus drugs have emerged.Therefore,it is urgent to develop antiviral drugs with new targets or mechanisms of action.RNA-dependent RNA polymerase is directly responsible for viral RNA transcription and replication,and plays key roles in the viral life cycle,which is considered an important target of anti-influenza drug design.From the point of view of medicinal chemistry,this review summarizes current advances in diverse small-molecule inhibitors targeting influenza virus RNA-dependent RNA polymerase,hoping to provide valuable reference for development of novel antiviral drugs.
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