The pandemic of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has caused a serious impact on global public health and the economy.SARS-CoV-2 infiltrates host cells via its surface spike protein,which binds to angiotensin-converting enzyme 2 on the host cell membrane.As a result,small molecules targeting spike protein have emerged as a hotspot in anti-SARS-CoV-2 drug research.Activity screening is an important step in seeking small molecule drugs.Therefore,this article aims to review the biological activity evaluation methods of small molecule inhibitors targeting SARS-CoV-2 spike protein,with the goal of laying the foundation for the discovery of new anti-SARS-CoV-2 drugs.
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