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多糖体内过程与免疫调节机制研究方法和技术进展

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近年来，多糖因其安全性高、免疫活性好受到广泛关注。多糖体内过程的研究是多糖药物开发亟待解决的关键科学问题。目前在多糖药代动力学和免疫调节领域研究取得了一定进展。然而，由于多糖既缺少生色基团，又无光吸收基团，且多糖本身分子结构复杂，致使多糖体内过程和免疫调节作用机制的研究进展缓慢。有效地结合多种技术手段可以突破多糖体内难示踪、免疫调节机制不明的瓶颈，促进多糖的开发与利用。本文系统归纳总结了近年来在多糖体内过程及其免疫调节作用机制研究中的关键技术，以期为多糖的体内过程及免疫调节机制的研究提供技术借鉴和研究思路。
Advances in methods and techniques for the study of polysaccharide in vivo processes and immunomodulatory mechanisms
In recent years,polysaccharides have received much attention because of their high safety and good immunological activity.The study of polysaccharide in vivo process is a key scientific problem that needs to be solved for polysaccharide drug development.Some progress has been made in the field of polysaccharide pharma-cokinetics and immunomodulation.However,due to the lack of both chromogenic and light-absorbing groups and the complex molecular structure of polysaccharides,the in vivo processes and immunomodulatory mechanisms of polysaccharides have been slow to be investigated.The effective combination of multiple techniques can break the bottleneck of difficult tracing and unknown immunomodulatory mechanism of polysaccharides in vivo,and promote the development and utilization of polysaccharides.In this paper,we systematically summarize the key techniques in the study of polysaccharide in vivo processes and immunomodulatory mechanisms in order to provide technical references and research ideas for the study of polysaccharide in vivo processes and immuno-modulatory mechanisms.

polysaccharidepharmacokineticsimmunomodulationmechanism of actionnew technology

朱赤云、肖平、方悦悦、赖梦亭、段金廒

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南京中医药大学江苏省中药资源产业化过程协同创新中心/中药资源产业化与方剂创新药物国家地方联合工程研究中心/国家中医药管理局中药资源循环利用重点研究室,江苏南京 210023

多糖 药代动力学 免疫调节 作用机制 新技术

江苏省中医药科技发展计划江苏省中药资源产业化过程协同创新中心重点项目国家自然科学基金南京中医药大学自然科学研究青年项目国家中医药局中医药创新团队及人才支持计划山东省重点研发计划

MS2021004ZDXM-2022-0681703642NZY81703642ZYYCXTD-D-2020052021SFGC1203

2024

10.16438/j.0513-4870.2023-0473

药学学报
中国药学会 中国医学科学院药物研究所

药学学报

CSTPCD北大核心
影响因子：1.274
ISSN：0513-4870
年,卷(期)：2024.59(2)
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