In recent years,polysaccharides have received much attention because of their high safety and good immunological activity.The study of polysaccharide in vivo process is a key scientific problem that needs to be solved for polysaccharide drug development.Some progress has been made in the field of polysaccharide pharma-cokinetics and immunomodulation.However,due to the lack of both chromogenic and light-absorbing groups and the complex molecular structure of polysaccharides,the in vivo processes and immunomodulatory mechanisms of polysaccharides have been slow to be investigated.The effective combination of multiple techniques can break the bottleneck of difficult tracing and unknown immunomodulatory mechanism of polysaccharides in vivo,and promote the development and utilization of polysaccharides.In this paper,we systematically summarize the key techniques in the study of polysaccharide in vivo processes and immunomodulatory mechanisms in order to provide technical references and research ideas for the study of polysaccharide in vivo processes and immuno-modulatory mechanisms.
关键词
多糖/药代动力学/免疫调节/作用机制/新技术
Key words
polysaccharide/pharmacokinetics/immunomodulation/mechanism of action/new technology
维普
万方数据