Natural products are important sources for the discovery of anti-tumor drugs.Evodiamine is the main alkaloid component of the traditional Chinese herb Wu-Chu-Yu,and it has weak antitumor activity.In recent years,a number of highly active antitumor candidates have been discovered with a significant progress.This article reviews the research progress of evodiamine-based antitumor drug design strategies,in order to provide reference for the development of new drugs with natural products as leads.
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