The lymphatic system,as well as pathological changes of the lymphatic system,underlies the progress of an array of diseases and conditions,including cancer,inflammation and autoimmune disorders,infectious diseases and metabolic syndrome.A variety of biological targets in the lymphatic system can be employed to modulate these high-burden diseases,and the pharmacokinetics and drug delivery strategies in the context of lymphatics are of critical importance to optimise drug exposure to lymphatic-related targets.As such,research and drug development in this field has gained increasing attention in recent years.This article aims to provide an overview of pharmaceutical research with a focus on the lymphatic system and therapeutic targets within the lymphatics,followed by lymphatic drug delivery approaches,which may be of interest for researchers in academia,pharmaceutical industry and regulatory sciences.
关键词
淋巴系统/淋巴药物递送/免疫治疗/大分子药物代谢动力学/纳米药物
Key words
lymphatic system/lymphatic drug delivery/immunotherapy/pharmacokinetics of macromole-cules/nanomedicine
维普
万方数据