Parkinson's disease(PD)is a chronic neurodegenerative disease.At present,levodopa and other drugs are mainly used for dopamine supplementation therapy.However,the absorption of levodopa in the gastrointestinal tract is unstable and its half-life is short,and long-term use of levodopa will lead to the end-of-dose deterioration,dyskinesia,the"ON-OFF"phenomenon and other symptoms.Therefore,new preparations need to be developed to improve drug efficacy,reduce side effects or improve compliance of patients.Based on the above clinical needs,this review briefly introduced the preparation modification strategies for the treatment of PD through case analysis,in order to provide references for the research and development of related preparations.
关键词
帕金森病/左旋多巴/卡比多巴/多巴胺受体激动剂/剂型
Key words
Parkinson's disease/levodopa/carbidopa/dopamine agonist/dosage form
维普
万方数据