In the past few decades,microbubbles were widely used as ultrasound contrast agents in the field of tumor imaging.With the development of research,ultrasound targeted microbubble destruction technology combined with drug-loaded microbubbles can achieve precise drug release and play a therapeutic role.As a micron-scale carrier,microbubbles are difficult to penetrate the endothelial cell space of tumors,and nano-scale drug delivery system—nanobubbles came into being.The structure of the two is similar,but the difference in size highlights the unique advantages of nanobubbles in drug delivery.Based on the classification principle of shell materials,this review summarized micro/nanobubbles used for ultrasound diagnosis or treatment and discussed the possible development directions,providing references for the subsequent development.
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