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无针注射技术的研究进展

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无针注射技术(needle-free injection technology,NFIT)是指药物在压力源作用下形成高速喷射流,透过皮肤到达合适深度的药物递送技术。NFIT可以递送液体、粉末和储库型制剂,具有防止意外针刺伤、提高药物生物利用度、消除针头恐惧、增加疫苗免疫效果、简化操作及易于患者自用等优势,是一种非常有潜力的递送药物方式。本文系统介绍了NFIT的研究背景、无针注射器的结构组成及可递送药物、影响注射效果的因素,并且总结了目前该技术的局限性和发展方向,为NFIT的应用和发展提供理论基础。
Research progress of needle-free injection technology
Needle-free injection technology(NF1T)refers to the drug delivery systems in which drugs are propelled as high-speed jet streams using any of the pressure source to penetrate the skin to the required depth.NFIT is a promising drug delivery system as it enables the injection of liquids,powders,and depot/projectiles,and has the advantages of preventing needle stick accidents,improving drug bioavailability,eliminating needle-phobia,increasing vaccine immunity,simplifying operations and is convenient for patients to use.NFIT and its research background,the structure and classification of needle-free jet injectors(NFJ1),drugs that can be delivered using NFJI and the factors affecting the injection effect are comprehensively reviewed in this paper.The limitations and potential development directions are summarized to provide a theoretical basis for the application and development of NFIT.

needle-free injection technologyneedle-free jet injectordrug delivery systempressure sourcevaccine

张郃、李硕、程艺、王增明、刘楠、李蒙、张慧、郑爱萍

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军事科学院军事医学研究院毒物药物研究所,北京 100850

联勤保障部队第九○九医院/厦门大学附属东南医院药剂科,福建漳州 363000

解放军总医院京南医疗区,北京 100850

无针注射技术 无针注射器 药物递送 压力源 疫苗

国家重点研发计划

2023YFC2706100

2024

药学学报
中国药学会 中国医学科学院药物研究所

药学学报

CSTPCD北大核心
影响因子:1.274
ISSN:0513-4870
年,卷(期):2024.59(3)
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