At present,there is no cure for acquired immune deficiency syndrome(AIDS)due to HIV-1 latent reservoirs.Therefore,it urgently requires novel HIV-1 latency-regulating agents with high potency,low toxicity and favorable drug-like properties to achieve a functional cure for AIDS.Herein,we reviewed the advances in HIV-1 latency-regulating agents since 2019,including the drug discovery strategies,bioactivities,and mechanisms of these compounds.It is of great guiding significance in the development of latency-regulating agents with clinical value.
acquired immune deficiency syndromeHIV-1 latent reservoirsfunctional cureshock and killblock and lock
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