益智仁中三个新的倍半萜类化合物
Three new sesquiterpenoids from the Alpiniae oxyphyllae Fructus
卢波涛 1朱跃通 1刘晓宁 1牛惠莹 1张梦雨 1冯卫生 2王彦志2
作者信息
- 1. 河南中医药大学药学院,河南郑州 450046
- 2. 河南中医药大学药学院,河南郑州 450046;呼吸疾病中医药防治省部共建协同创新中心,河南郑州 450046
- 折叠
摘要
用MCI Gel CHP-20、Sephadex LH-20、ODS和硅胶等柱色谱,结合半制备液相和TLC等分离方法对益智仁(Alpinia oxyphylla Fructus)70％乙醇提取物的正丁醇部位进行分离纯化,从益智仁正丁醇部位中分离纯化得到1个新的C-4/C-5位开环的卤代桉叶烷型倍半萜和两个新的艾里莫酚烷型倍半萜.运用现代波谱学方法(1D、2D NMR,UV,IR,MS等)对所分离得到的化合物进行结构鉴定,并运用计算ECD和衍生CD的方法确定了新化合物的绝对构型.
Abstract
The n-butanol fraction of Alpinia oxyphylla Fructus 70％ethanol extract was separated and purified using column chromatography with MCI Gel CHP-20,Sephadex LH-20,ODS,and silica gel,combined with semi preparative liquid phase and TLC separation methods.One new halogenated 4,5-seco-eudesmane sesquiterpenoid and two new eremophilane sesquiterpenoids were isolated and purified from the n-butanol fraction of Alpinia oxyphylla Fructus.The structures of the isolated compounds were identified using modem spectroscopic methods(1D,2D NMR,UV,IR,MS,etc.),and the absolute configuration of the new compounds were determined using the methods of calculated ECD and induced ECD.
关键词
益智仁/化学成分/分离鉴定/桉叶烷型倍半萜/艾里莫酚烷型倍半萜Key words
Alpinia oxyphylla Miq/chemical composition/separation and identification/seco-eudesmane sesquiterpenoid/eremophilane sesquiterpenoid引用本文复制引用
出版年
2024
NETL
NSTL
万方数据