用MCI Gel CHP-20、Sephadex LH-20、ODS和硅胶等柱色谱,结合半制备液相和TLC等分离方法对益智仁(Alpinia oxyphylla Fructus)70％乙醇提取物的正丁醇部位进行分离纯化,从益智仁正丁醇部位中分离纯化得到1个新的C-4/C-5位开环的卤代桉叶烷型倍半萜和两个新的艾里莫酚烷型倍半萜.运用现代波谱学方法(1D、2D NMR,UV,IR,MS等)对所分离得到的化合物进行结构鉴定,并运用计算ECD和衍生CD的方法确定了新化合物的绝对构型.
Three new sesquiterpenoids from the Alpiniae oxyphyllae Fructus
The n-butanol fraction of Alpinia oxyphylla Fructus 70％ethanol extract was separated and purified using column chromatography with MCI Gel CHP-20,Sephadex LH-20,ODS,and silica gel,combined with semi preparative liquid phase and TLC separation methods.One new halogenated 4,5-seco-eudesmane sesquiterpenoid and two new eremophilane sesquiterpenoids were isolated and purified from the n-butanol fraction of Alpinia oxyphylla Fructus.The structures of the isolated compounds were identified using modem spectroscopic methods(1D,2D NMR,UV,IR,MS,etc.),and the absolute configuration of the new compounds were determined using the methods of calculated ECD and induced ECD.
Alpinia oxyphylla Miqchemical compositionseparation and identificationseco-eudesmane sesquiterpenoideremophilane sesquiterpenoid
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