Mechanisms of Acinetobacter baumannii iron acquisition and antimicrobial strategies based on the inhibition of iron uptake
Bacterial resistance has always been a challenge in the field of antibacterials research.As one of the most problematic pathogens causing nosocomial infections,Acinetobacter baumannii(A.baumannii)was a severe threaten to public health.In recent years,as the rate of multidrug-resistant,extensively drug-resistant,and even pan drug-resistant A.baumannii has been increasing,there is an urgent need to develop new strategies to combat this pathogen.Iron is an essential element for the survival and the infection process of A.baumannii.Bacteria have developed a series of iron uptake strategies to survive in conditions of the host iron starvation,including the secretion of siderophore for iron chelation,the uptake of ferroheme,and the transport of ferrous by Feo system.Developing antibacterial strategies to inhibit the iron uptake is an effective way to deal with A.baumannii infection.This article will review the mechanisms of iron uptake by A.baumannii and the antimicrobial strategies developed based on them.
host iron starvationacquisition of ironAcinetobacter baumanniibacterial resistanceantimicrobial strategy
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