鲍曼不动杆菌铁离子摄取机制与基于抑制铁摄取的抗菌策略
Mechanisms of Acinetobacter baumannii iron acquisition and antimicrobial strategies based on the inhibition of iron uptake
张芷萌 1游雪甫 1庞晶1
作者信息
- 1. 中国医学科学院、北京协和医学院医药生物技术研究所,抗感染北京市重点实验室,北京 100050
- 折叠
摘要
细菌耐药一直是抗感染药物研究领域亟待攻克的难题.鲍曼不动杆菌作为引起院内感染的重要病原菌,严重威胁患者的生命健康.近年来,多重耐药、泛耐药,甚至全耐药鲍曼不动杆菌的检出率不断升高,因此开发新的治疗鲍曼不动杆菌感染的策略迫在眉睫.铁是鲍曼不动杆菌生存必需的基本元素,也是参与感染进程的重要物质.细菌为了应对宿主铁饥饿现象,发展了一系列铁摄取手段,如分泌铁载体螯合铁、摄取血红素、利用Feo系统转运亚铁等.开发相应的抗菌策略以抑制鲍曼不动杆菌的铁摄取,是应对鲍曼不动杆菌感染的有效手段.本文将从鲍曼不动杆菌铁摄取机制以及基于此机制发展的抗菌策略两个方面进行综述.
Abstract
Bacterial resistance has always been a challenge in the field of antibacterials research.As one of the most problematic pathogens causing nosocomial infections,Acinetobacter baumannii(A.baumannii)was a severe threaten to public health.In recent years,as the rate of multidrug-resistant,extensively drug-resistant,and even pan drug-resistant A.baumannii has been increasing,there is an urgent need to develop new strategies to combat this pathogen.Iron is an essential element for the survival and the infection process of A.baumannii.Bacteria have developed a series of iron uptake strategies to survive in conditions of the host iron starvation,including the secretion of siderophore for iron chelation,the uptake of ferroheme,and the transport of ferrous by Feo system.Developing antibacterial strategies to inhibit the iron uptake is an effective way to deal with A.baumannii infection.This article will review the mechanisms of iron uptake by A.baumannii and the antimicrobial strategies developed based on them.
关键词
宿主铁饥饿/铁摄取/鲍曼不动杆菌/细菌耐药/抗菌策略Key words
host iron starvation/acquisition of iron/Acinetobacter baumannii/bacterial resistance/antimicrobial strategy引用本文复制引用
出版年
2024
NETL
NSTL
万方数据