Three new sesquiterpenes from Xylopia vielana Pierre and their effects of farnesoid X receptor activation
Eleven compounds were isolated from the twigs and leaves of Xylopia vielana Pierre by various chromatographic techniques such as silica gel,ODS and the semi-preparative HPLC.Their chemical structures were identified by HR-ESI-MS,NMR,ECD and other spectroscopic methods as vielana A(1),vielana B(2),vielana C(3),10-oxo-isodauc-3-en-15-al(4),1α-hydroxyisodauc-4-en-15-al(5),mokko lactone(6),11β,13-dihy-drocostunolide(7),eurylosesquiterpenol E(8),epi-α-cadinol(9),mustakone(10),7-epi-amiteo(11).Among them,compounds 1-3 were new compounds,and the rest compounds were isolated from this plant for the first time.Compounds 1 and 2 increased the transcriptional activity of the famesoid X receptor(FXR)downstream target gene BSEP promoter,indicating that they have potential of FXR activation.
Xylopia vielana Pierrechemical constituentsesquiterpenefarnesoid X receptor
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