靶向血小板-免疫细胞相互作用作为心肌梗死后治疗的新策略——当前证据和未来展望
Targeting platelet-immune cell interaction as a new strategy for post-myocardial infarction current evidence and future prospective
韩林宏 1赵玉涵 1王晓英 2朱彦1
作者信息
- 1. 天津中医药大学,组分中药国家重点实验室,天津 301617;现代中医药海河实验室,天津 301617
- 2. 杜兰大学医学院临床神经科学研究中心神经外科系,美国新奥尔良70112
- 折叠
摘要
心肌梗死是高发病率和高死亡率的致命疾病.血小板是急性心肌梗死后血栓形成和炎症的主要因素.越来越多证据表明,血小板通过直接或间接途径与免疫细胞相互作用介导炎症、参与死亡组织清除和心脏重塑.本文综述了心肌梗死后血小板与免疫细胞之间相互作用的类型,并总结了血小板与不同免疫细胞(如中性粒细胞、单核细胞和巨噬细胞)相互作用的机制,尤其是心肌梗死后通过上调表面受体和释放免疫调节介质介导心肌损伤和修复.本文还提出了针对血小板与免疫细胞相互作用的心肌梗死治疗策略,为探索新的心肌梗死免疫治疗靶点提供参考.
Abstract
Myocardial infarction(MI)is a fatal disease with high morbidity and mortality.Platelets are major players of thrombosis and inflammation after acute myocardial infarction.There is growing evidence that platelets mediate inflammation,participate in dead tissue removal and heart remodeling through direct or indirect interactions with immune cells post-MI.This paper reviews the type of interactions between platelets and immune cells after myocardial infarction,and summarizes the mechanism of platelet interaction with different immune cells,such as neutrophils,monocytes,and macrophages,to mediate cardiac injury and repair through up-regulation of surface receptors and release of immune regulatory mediators post-MI.Therapeutic strategies targeting the interaction between platelets and immune cells for myocardial infarction is also presented,to provide reference for the exploration of new immune therapy targets for myocardial infarction.
关键词
心肌梗死/炎症/血小板/免疫细胞/通信Key words
myocardial infarction/inflammation/blood platelet/immune cell/communication引用本文复制引用
基金项目
国家重点研发计划项目(2018YFC1704502)
国家自然科学基金资助项目(81873037)
出版年
2024
NETL
NSTL
万方数据