Advances in the construction of models and applications of Alzheimer's disease based on microfluidic chips
Alzheimer's disease(AD)isa progressive neurodegenerative disease associated with dysfunctions related to thinking,learning,and memory of the brain.AD has multiple pathological characteristics with complicated causes,constructing a suitable pathological model is crucial for the research of AD.Microfluidic chip technology integrates multiple functional units on a chip,which can realize microenvironmental control similar to the physiological environment.It is well applied in the construction of pathological model,early diagnosis as well as drug screening of AD.This paper focuses on the construction of AD microfluidic chips model from the perspective of cell type,culture formats and the chips structure as well as the research progress of microfluidic chips in AD application based on the pathological characteristics of AD,which will provide a reference for further elucidation of AD mechanism and drug development.
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