药物纳米晶自稳定Pickering乳液给药系统研究的关键问题
Key issues in the study of drug nanocrystals self-stabilized Pickering emulsions as drug delivery system
张继芬 1董芳明 1刘川 2易涛3
作者信息
- 1. 西南大学药学院,重庆 400716
- 2. 成都市食品检验研究院,四川成都 611130
- 3. 澳门理工大学健康科学及体育学院,澳门 999078
- 折叠
摘要
药物纳米晶自稳定 Pickering乳液(drug nanocrystals self-stabilized Pickering emulsion,DNSPE)是一种以药物自身纳米晶为稳定剂的新型Pickering乳液,近年来在药物递送领域的研究越来越多.本文在总结药物递送DNSPE研究现状的基础上,全面综述影响其构建的主要因素、性质与结构的表征方法、体内命运等关键问题的研究进展,并展望产业化前景,以期为深化DNSPE的全面研究,促进其在药物递送领域的应用提供参考.
Abstract
Drug nanocrystals self-stabilized Pickering emulsion(DNSPE)is a novel Pickering emulsion with drug nanocrystals as the stabilizer.There are more and more researches on DNSPE in the field of drug delivery in recent years.On the basis of summarizing the research status of DNSPE used as drug delivery systems,this paper comprehensively reviewed the research progress of three key issues,such as the main factors affecting construction of DNSPE,characterization methods of properties and structures,and in vivo fate,and looked forward to the industrialization prospect,which is beneficial to deepen the comprehensive research of DNSPE and promote its application in the field of drug delivery.
关键词
Pickering乳液/药物递送/纳米晶/结构表征/体内命运Key words
Pickering emulsion/drug delivery/nanocrystal/structure characteristic/fate in vivo引用本文复制引用
基金项目
重庆市科卫联合中医药科研项目重点项目(2023ZDXM034)
澳门科学技术发展基金资助项目(0061/2023/RIA1)
澳门理工大学资助研究项目(RP/FCSD-01/2023)
出版年
2024
NETL
NSTL
万方数据