Macroporous adsorption resin,MCI,Toyopearl HW-40C and silica gel column chromatography combined with the semi-preparative HPLC were used to isolate and purify the water extract of Cornus officinalis.And the structures of compounds were identified by HRESIMS,NMR,IR,UV and ECD.A total of twelve com-pounds were isolated from the fruits of Cornus officinalis.They were identified as neolignan B(1),2,3-dihydro-7-methoxy-2-(4'-hydroxy-3'-methoxyphenyl)-3a-O-β-D-xylopyranosyloxymethyl-5-benzofuranpropanol(2),cornuca-dinoside A(3),3,4-dihydroxyacetophenone(4),n-butyl gallate(5),3-hydroxybenzoic acid(6),n-butyl quininate(7),5-hydroxymaltol(8),2-furolic acid(9),5-hydroxymethylfurfural(10),5-(methoxycarbonyl)-2-pyrrolidone(11),and dimethyl malate(12).Compound 1 is a new biphenyl lignan,named as neolignan B.Compounds 2,4,5,7-9 and 11 were isolated from Cornus officinalis for the first time.
Cornus officinalischemical constituentneolignan Bbiphenyl lignanisolation and identifica-tion
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