Palatability evaluation of oral iron for children based on in vivo and in vitro evaluation techniques
Oral iron is a commonly used preparation for the treatment of iron deficiency and iron-deficiency anemia in children,but its undesirable taste has become a major factor affecting clinical adherence to the medication.No studies have been conducted to evaluate the palatability of oral iron supplements.Thirteen representative oral iron supplements were selected to evaluate the palatability of oral iron supplements from different perspectives of in vivo and ex vivo by combining the electronic tongue(e-tongue)test,FaceReader facial expression analysis technology and taste interviews.E-tongue test results showed that iron dextran granlues were closest to odorless potassium chloride solution,basically free of bitterness and astringency,which was superior to the other products.FaceReader facial expression results showed that 58.7％of the subjects valued iron dextran granlues for their emotional efficacy higher than that of iron proteinsuccinylate oral solution.Among 43 participants aged ≥ 5 years,the taste preference for iron dextran granlues was 83.7％,and 83.7％of participants chose to take iron dextran granlues again.This study found that iron dextran granlues have a better taste and their flavor is more popular among children,which provides a reference for pediatric clinical use of oral iron supplementation preparations and a new idea for the evaluation of palatability of medications for children.This in vivo palatability evaluation is an investigational clinical trial that was approved by the Institutional Review Board of the Beijing Children's Hospital(No.2021-149-Y).
NETL
NSTL
万方数据
