Research progress on the antitumor efficacy improvement for nanomedicine by combinatorial modification with multiligand
After entering the body from the drug delivery site,antitumor nanomedicines need to cross a series of physiopathological barriers to reach the target site of action to effectively exert antitumor therapeutic effects.The ligand modification strategy is a classic method to enhance the efficiency of nanomedicine delivery in vivo,but the contradiction between the single ligand modification strategy,which is characterized by unity and stage,and the in vivo delivery process,which is characterized by versatility and whole-process characteristics,determines that nanomedicines modified by a single ligand alone cannot satisfy the target efficacy requirements.Therefore,the use of multiligand combinatorial modification strategies by virtue of nanomedicine surface area advantages is key to advancing the next generation of smart nanomedicines.In this paper,on the basis of summarizing and classifying the commonly used functional ligands for in vivo delivery,the advantages and research progress of multiligand combination modification of antitumor nanomedicines are discussed with special focus,and the multiligand combination modification is classified as synergistic and complementary according to the combination of the ligands,which is of great significance to ensure that antitumor nanomedicines can overcome the multiple physiopathological barriers to achieve precise delivery.
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