多配基组合修饰提升抗肿瘤纳米药物功效的研究进展
Research progress on the antitumor efficacy improvement for nanomedicine by combinatorial modification with multiligand
张小雨 1吴送姑 1徐晖 2龚俊波 1邢金峰 1魏振平1
作者信息
- 1. 天津大学化工学院,天津 300350
- 2. 沈阳药科大学药学院,辽宁沈阳 110016
- 折叠
摘要
抗肿瘤纳米药物从给药位置进入体内后,还需跨越一系列生理病理障碍,到达目标作用位置才能有效发挥抗肿瘤疗效.配基修饰策略是提升纳米药物体内递送效率的经典方法,但具有单一性和阶段性特点的单配基修饰策略与具有多变性和全过程性特点的体内递送进程之间的矛盾,决定了仅使用单一配基修饰的纳米药物不能满足目标药效需求.所以凭借纳米药物表面积优势使用多配基组合修饰策略是推进新一代智能纳米药物的关键,本文在对应体内递送进程总结分类了常用功能配基的基础上,重点讨论了多配基组合修饰抗肿瘤纳米药物的优势及研究进展,并依据配基组合方式将多配基组合修饰分为协同型及互补型,这对于保障抗肿瘤纳米药物顺利克服多重生理病理障碍实现精准递送具有重要意义.
Abstract
After entering the body from the drug delivery site,antitumor nanomedicines need to cross a series of physiopathological barriers to reach the target site of action to effectively exert antitumor therapeutic effects.The ligand modification strategy is a classic method to enhance the efficiency of nanomedicine delivery in vivo,but the contradiction between the single ligand modification strategy,which is characterized by unity and stage,and the in vivo delivery process,which is characterized by versatility and whole-process characteristics,determines that nanomedicines modified by a single ligand alone cannot satisfy the target efficacy requirements.Therefore,the use of multiligand combinatorial modification strategies by virtue of nanomedicine surface area advantages is key to advancing the next generation of smart nanomedicines.In this paper,on the basis of summarizing and classifying the commonly used functional ligands for in vivo delivery,the advantages and research progress of multiligand combination modification of antitumor nanomedicines are discussed with special focus,and the multiligand combination modification is classified as synergistic and complementary according to the combination of the ligands,which is of great significance to ensure that antitumor nanomedicines can overcome the multiple physiopathological barriers to achieve precise delivery.
关键词
纳米药物/协同型组合修饰/互补型组合修饰/肿瘤递送Key words
nanomedicine/synergistic combinatorial modification/complementary combinatorial modifica-tion/tumor delivery引用本文复制引用
基金项目
国家自然科学基金资助项目(22078234)
国家自然科学基金资助项目(22178254)
出版年
2024
NETL
NSTL
万方数据