Advances in the study of gastrointestinal microneedles for oral delivery of biomacromolecule drugs
Biomacromolecule drugs have been increasingly used in clinical practice due to their distinct advantages,including precise targeting,small dose,high safety and activity.However,owing to their high molecular weight,strong hydrophilicity,and poor stability in the gastrointestinal tract,the oral bioavailability of the biomacromolecule drugs remains extremely poor.As a novel and innovative technology for active drug delivery,gastrointestinal microneedles hold immense potential in the oral delivery of biomacromolecule drugs because of their low-invasive nature and high permeation enhancement effects.This review primarily summarizes the actuating force,design strategies,fabrication techniques,and applications of gastrointestinal microneedles for the oral delivery of biomacromolecule drugs.Additionally,the challenges and further perspectives in the development this technology are presented,aiming to promote the subsequent research and clinical translation of gastrointestinal microneedles,and to provide a new efficient and safe strategy for oral delivery of biomacromolecule drugs.
gastrointestinal microneedlebiomacromoleculeoral drug deliverybioavailability
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