Studies on the chemical composition of Ferula feruloides
Eleven compounds were isolated and purified from the ethyl acetate part of 80％ethanol extract of Ferula feruloides root by a combination of normal-phase silica gel column chromatography,Sephadex LH-20 dextran gel column chromatography and semi-preparative liquid chromatography and then modern wave spectrometry methods(NMR,MS,UV,IR)were used to identify the structures of the compounds,which were identified as baigene D(1),baigene E(2),baigene F(3),β-kirialovin(4),α-kirialovin(5),falcarindiol(6),ammoresinol(7),dshamirone(8),2,3-dihydro-7-hydroxy-2S*,3R*-dimethyl-3-[4-methyl-5-(4-methy 1-2-furyl)-3(E)-pentenyl]-furo[3,2-c]coumarin(9),2,3-dihydro-7-hydroxy-2S*,3R*-dimethyl-2-[4,8-dimethyl-3(E),7-nonadi-enyl]-furo[3,2-c]coumarin(10),and baigene C(11).Compounds 1-3 are new coumarin analogues,and compounds 4-6 are firstly isolated from F feruloides.The anti-proliferative activity of compounds 5,7-11 against human gastric cancer(MKN-45)cells was evaluated using MTT assay,which showed that compounds 7-11 exhibited strong inhibitory activity,and compound 5 exhibited weak inhibitory activity.
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