Development of analgesic drugs targeting Nav1.7:advances in clinical trials and discovery of selective inhibitors
The voltage-gated sodium channel subtype Nav1.7 is highly expressed in nociceptive sensory neurons and is a key pathogenic target in several human hereditary pain syndromes.In recent years,a large number of studies have shown that Nav1.7 plays an important role in inflammatory,neuropathic,and nociceptive pain.Therefore,targeting Nav1.7 is a new strategy and hotspot for the development of novel analgesics.This review introduces the structure and function of Nav1.7,its regulatory role in pain,highlights the development progress of small-molecule Nav1.7 inhibitors in clinical trials,and analyzes the preclinical development of highly specific Nav1.7 inhibitors,with a view to providing reference for the development of Nav1.7 analgesic drugs.
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