微针递送生物技术药物的研究进展
Progress in delivering biotechnology drugs on microneedles
刘寒 1杨国忠 1杜菀人 1张锁慧 2周泽荃 1高云华2
作者信息
- 1. 中科微针(北京)科技有限公司,北京 100000
- 2. 中科微针(北京)科技有限公司,北京 100000;中国科学院理化技术研究,北京 100000
- 折叠
摘要
微针作为一种新型的透皮给药系统,能够显著改善皮肤的渗透性,增强药物的透皮递送效果,在突破皮肤角质层屏障方面显示出独特的优势.这一特性使得微针给药系统在生物技术药物的递送方面展现出巨大的潜力.传统的生物技术药物递送途径主要是注射给药,这种方式给患者带来疼痛、皮肤红肿等问题,导致患者依从性较差.此外,生物技术药物的生产、运输和储备都需要严格的低温条件来保持其活性,增加成本.相比之下,微针给药系统具有诸多优势,为生物技术药物的递送提供了新的途径和解决方案.本文对递送生物技术药物的微针给药系统进行概述,总结了微针体系在生物技术药物方面的研究进展.
Abstract
As a new transdermal drug delivery system,microneedles can significantly improve skin permeability,enhance drug transdermal delivery,and demonstrate unique advantages in breaking stratum corneum barrier of skin.This feature enables microneedles to demonstrate enormous potential in delivering biotechnology drugs.The traditional delivery method for biotechnology drugs is mainly injection,which brings problems such as pain and skin redness to patients,leading to poor patient compliance.In addition,the production,transportation,and storage of biotechnology drugs require strict low-temperature conditions to maintain their activity and increase cost output.Microneedles,by contrast,have many benefits,providing new avenues and solutions for biomolecular delivery.Accordingly,this review introduced the microneedle drug delivery system for delivery biotechnology drugs,and summarized the research progress of microneedle systems in biotechnology drugs.
关键词
微针/经皮递送/生物技术药物/分类/稳定性Key words
microneedle/transdermal delivery/biotechnology drug/classification/stability引用本文复制引用
基金项目
重庆市科技局科研机构绩效激励引导专项(2023JXJL-YFX0068)
出版年
2024
NETL
NSTL
万方数据