苏合香中一个新的松香烷二萜
A new abietane diterpene from the Styrax
冯结楠 1程永现1
作者信息
- 1. 广东药科大学药学院,广东广州 510006;广东省中药有效成分与肠道微生物组学重点实验室,深圳大学中医药守正创新研究院,深圳大学医学部药学院,广东深圳 518060
- 折叠
摘要
运用MCI Gel CHP20P、SephadexLH-20、ODS和硅胶等柱色谱,结合TLC、半制备液相色谱等分离纯化方法,从苏合香水提物的95％乙醇溶解物中得到12个松香烷二萜化合物.运用1D、2D NMR、UV、MS等现代波谱学方法对所分离得到的化合物进行结构鉴定,并运用计算ECD的方法确定了新化合物的绝对构型.其中,化合物1为新化合物,鉴定为(4R,5R,9S,10R,12S)-12-methoxy-neoabietic acid,化合物2～12为首次从苏合香中分离得到.
Abstract
Twelve abietane diterpenes were isolated from the 95％ethanol fraction solvated from the aqueous extract of Styrax by using various chromatographic methods,including MCI Gel CHP 20P,Sephadex LH-20,ODS,silica gel,TLC and semi-preparative HPLC.The structures of the isolated compounds were identified by spectroscopy methods(1D,2D NMR,UV,MS,etc.),and the absolute configuration of the new compound was determined by ECD calculations.Compound 1 is a new compound,which was identified as(4R,5R,9S,10R,12S)-12-methoxy-neoabietic acid,and compounds 2-12 were isolated from Styrax for the first time.
关键词
苏合香/树脂/松香烷型二萜/提取分离/结构鉴定Key words
Styrax/resin/abietane diterpenes/extraction and separation/structural identification引用本文复制引用
出版年
2024
NETL
NSTL
万方数据