基于刺五加中药渣制备的三维有序多孔炭材料及其载药性能研究
Research on three-dimensional ordered porous carbon-based materials prepared from Acanthopanax senticosus traditional Chinese medicine residues and their drug loading performance
王德升 1范嘉欣 1成日青 1武世奎 1王来兵 1师嘉浩 1陈婷婷 1何琴芳 1徐长进 1郭慧卿1
作者信息
- 1. 内蒙古医科大学药学院,内蒙古呼和浩特 010110
- 折叠
摘要
三维有序多孔炭材料由于其高比表面积、可调控的孔径结构和优异的生物相容性,在药物传递系统中作为优异的药物载体展现出潜在的应用前景.本文以刺五加中药渣为原料,KOH为活化剂,采用一步热解法制备三维有序多孔炭材料.利用X-射线衍射仪、扫描电子显微镜、氮气吸附-脱附、傅里叶变换红外光谱等手段对制备的三维有序多孔炭材料进行了结构表征.结果表明:以KOH为活化剂,采用热分解法制备的三维有序多孔炭材料具有丰富的官能团、高空隙率和高比表面积,其比表面积为1 471.6 m2·g-1.在800 ℃下制备的三维有序多孔炭材料对5-氟尿嘧啶具有高载药率(78.0％)和释药率(86.8％).三维有序多孔炭材料在药物构建中展现出显著的应用优势,其高比表面积和可调控的孔径结构显著提高了药物负载率和释药率,为开发高效、精准的药物传递系统提供了坚实的基础.
Abstract
Three-dimensional ordered porous carbon materials exhibit potential application prospects as excellent drug supports in drug delivery systems due to their high specific surface area,tunable pore structure,and excellent biocompatibility.In this study,three-dimensional ordered porous carbon materials were prepared using Acanthopanax senticosus herbal residues as raw material and KOH as activating agent through a one-step pyrolysis method.The prepared carbon-based material was systematically characterized by powder X-ray diffraction,scanning electron microscopy,N2 adsorption-desorption and Fourier-transform infrared spectroscopy.The results show that the three-dimensional ordered porous carbon materials prepared with KOH as the activator via pyrolysis possess abundant functional groups,high porosity,and high specific surface area,with a specific surface area of 1 471.6 m2·g-1.The three-dimensional ordered porous carbon materials prepared at 800 ℃ exhibits a high drug loading capacity(78.0％)and drug release rate(86.8％)for 5-fluorouracil.Three-dimensional orderly porous carbon materials show significant application advantages in drug construction,and their high specific surface area and adjustable pore size structure significantly improve the drug load rate and drug release rate,providing a solid foundation for the development of efficient and accurate drug delivery system.
关键词
中药渣/刺五加/三维有序多孔炭材料/载药性能/释药性能Key words
Chinese medicine residue/Acanthopanax senticosus/three-dimensional ordered porous carbon material/drug loading performance/drug release performance引用本文复制引用
基金项目
国家自然科学基金资助项目(22168029)
内蒙古医科大学面上项目(YKD2023MS082)
内蒙古自然科学基金项目(2024QN05006)
出版年
2024
NETL
NSTL
万方数据