A new trichothecene macrolide from endophyte Myrothecium roridum associated with Trachelospermum jasminoides
Three compounds were obtained from the crude extract of the fermentation broth of endophyte Myrothecium roridum IFB-E008 in Trachelospermum jasminoides by silica gel column chromatography,Sephadex LH-20 gel column chromatography and high performance liquid chromatography.They were determined as 3'-iso-isororidin A(1),verrol(2)and N-acetyltryptamine(3),respectively,through HR-MS,1D and 2D NMR and literature comparison.3'-iso-isororidin A(1)is a new trichothecene macrolide that has never been reported in the literature.The in vitro cytotoxicity assay showed that compound 2 had certain cytotoxicity against the human gastric cell line SGC-7901 with half inhibition concentration(IC50)of 59.79 μg·mL-1(158.1 μmol·L-1),while IC50 value of the positive control cisplatin was 6.58 μg·mL-1(21.9 μmol·L-1).