Advances in the strategies of nasal into brain nanodelivery and the treatment of brain diseases
The blood-brain barrier limits the brain delivery of most drugs and affects the treatment of central nervous system disorders.The transnasal drug delivery allows the drug to bypass the blood-brain barrier and reach the brain directly through pathways such as the olfactory and trigeminal nerves,thus improving the therapeutic efficacy of the drug while reducing drug degradation and avoiding hepatic first pass effect.With the rise of nanotechnology,the combination of nanoformulations with transnasal routes of administration is expected to achieve better brain targeting and treatment of brain diseases.On the basis of summarizing the characteristics of the various nose-to-brain pathways,this review summarizes the researches on novel transnasal nanopreparations such as exosomes and liquid crystals in recent years as well as new strategies to improve the efficiency of brain entry including focused ultrasound-mediated techniques.We also review the recent studies on transnasal brain entry nanopreparations in the treatment of various brain disorders and current research dilemmas,looking forward to the prospect of their future clinical applications.
万方数据
维普
