The blood-brain barrier(BBB)plays a crucial role in maintaining the homeostasis of the brain's internal environment,which poses challenges to the treatment of central nervous system diseases.Drug carriers can aid in the delivery of therapeutic agents across the BBB to exert their pharmacological effects.The article reviewed the pathways for drug delivery across the BBB,the intracerebral fate and the classification of drug carriers and focuses on the functions and characteristics of liposomes,exosomes,apoptotic bodies,cell-penetrating peptides,and cell-targeting peptides.The review will provide an outlook on the future and challenge of research in the field of drug delivery across the BBB.
关键词
药物载体/血脑屏障/脑内命运/脂质体/外泌体/凋亡小体/细胞穿透肽/细胞靶向肽
Key words
drug carrier/blood-brain barrier/intracerebral fate/liposome/exosome/apoptotic body/cell-penetrating peptide/cell-targeting peptide
维普
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