The microsphere drug delivery systems have been extensively exploited for providing controllable drug release kinetics,enhancing drug stability and localized drug delivery.In past decade,dozens of microsphere drug delivery systems have been developed for clinical therapy of cancer,schizophrenia and neurodegenerative diseases(e.g.,Alzheimer's disease and Parkinsonism).In this review article,we comprehensively summarized the fabrication methods of drug delivery systems and highlighted their advances for clinical application.Furthermore,we analyzed the potential and the challenges for clinical translation of the drug delivery systems.
关键词
微球载药系统/制备方法/局部药物递送/药物储库/临床转化
Key words
microsphere drug delivery system/fabrication method/localized drug delivery/drug deposit/clinical translation
维普
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