Study on secondary metabolites of an endophytic fungi Alternaria tenuissima Pas85
A new alkaloid(1)and six known compounds(2-7)were isolated from the solid fermentation extract of the endophytic fungus Alternaria tenuissima Pas85 of Phragmites australis by silica gel column chromatography,Sephadex LH-20 column chromatography,high performance liquid chromatography and other chromatographic techniques.The structures of these compounds were determined by HREIMS,NMR,IR spectroscopy,and literature comparison,and the anti MRSA(methicillin-resistant Staphylococcus aureus)activity of 1-5 were tested.Compounds 1,2,3 and 4 exhibited certain inhibitory activity with MIC values of 64,4,32 and 32 μg·mL-1,respectively,and compound 5 showed no significant inhibitory activity.
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