Two new diphenyl ethers from the whole plant of Canscora lucidissima
Twelve compounds were isolated and purified from 95％ethanol extract of the whole plant of C.lucidissima by silica gel column chromatography,MCI column chromatography and ODS column chromatography,polyamide column chromatography,Sephadex LH-20 column chromatography,combined with semi-preparative HPLC methods.Based on the physicochemical properties and spectral data(UV,IR,MS,NMR),the structures of the isolates were identified as canlucdiphenyl ether A(1),canlucdiphenyl ether B(2),canlucbenzophenone A(3),(-)-pinoresinol(4),3-hydroxybenzoic acid(5),1,3,8-trihydroxy-6-hydroxymethylanthraquinone(6),dihydrokaempferol(7),6,7-dihydroxycoumarin(8),4-hydroxy-3,5-dimethoxybenzoic acid(9),4-hydroxy-3,5-dimethoxycinnamic acid(10),2-hydroxy-3-methoxybenzoic acid(11),(-)-syringaresinol(12).Among them,compounds 1 and 2 are two new diphenyl ether and 3 is a new natural product.Compound 8 exhibited some anti-inflammatory activity by inhibiting the lipopolysaccharide-induced NO production in RAW264.7 cells.
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