Study on improving the photostability of nifedipine by crystal engineering
In order to improve the poor photostability of nifedipine,this study designed a cocrystal based on the principles of crystal engineering and prepared nifedipine-imidazole cocrystal by suspension method.The new cocrystal was characterized by powder X-ray diffraction(PXRD),differential scanning calorimetry(DSC),thermogravimetric analysis(TG)and infrared spectroscopy(IR)to confirm the formation of the cocrystal.The photostability of nifedipine and its cocrystal was measured by powder X-ray diffraction and high-performance liquid chromatography(HPLC).The results showed that the nifedipine-imidazole cocrystal improved the photostability of nifedipine to a certain extent.This study provides guidance for the development of nifedipine cocrystals and the improvement of its druggability.
万方数据
维普
