Objective To systematically evaluate the correlation between peripheral blood natural killer(NK)cells and primary immune thrombocytopenia(ITP).Methods Pub Med,Springer Link,OVID,China national knowledge infrastructure(CNKI),VIP Chinese Sci-tech Periodicals(VIP),China Biomedical Literature Service System(Sino Med),Wanfang Medical Periodicals(WAN FANG)were searched comprehensively to find the studies on the relationship between NK cells and ITP.Meta-analysis was performed on the included studies using Review Manager 5.3 software.Results Finally,7 case-control studies were included,with a total of 514 subjects,including 302 in the ITP group and 212 in the control group.The results of Meta-analysis showed that there was a significant correlation between peripheral blood NK cell level and ITP(MD=-5.58,95％CI:-8.00 to-3.15,P＜0.000 01).The results of subgroup analysis showed that the level of NK cells in peripheral blood was significantly correlated with the newly diagnosed ITP(MD=-4.89,95％CI:-9.39 to-0.39,P=0.03).Conclusion There is a significant correlation between peripheral blood NK cell level and ITP.Targeted abnormal NK cells may have an impact on the occurrence and development of ITP,which provides a theoretical basis for its treatment plan.
NK cellPrimary immune thrombocytopenialmmune tolerance
国家科技期刊平台
NSTL
维普
万方数据
