Application Value of Transcatheter Arterial Chemoembolization with Pirarubicin-loaded Microspheres Combined with Apatinib Therapy in the Interventional Treatment of Patients with Primary Liver Cancer
Objective To investigate the effect of transcatheter arterial chemoembolization with pirarubicin-loaded microspheres combined with apatinib orally in the treatment of patients with primary liver cancer.Methods A total of 185 patients who underwent interventional therapy for primary liver cancer in Foshan First People's Hospital from January 2020 to June 2021 were selected as the research objects.According to different treatment methods,they were divided into observation group(93 patients)and control group(92 patients).The observation group was treated with pirarubicin-loaded microsphere TACE combined with apatinib,while the control group was treated with pirarubicin+lipiodol TACE combined with apatinib.The progression-free survival(PFS),overall survival,clinical total effective rate,alpha-fetoprotein(AFP)level and adverse reactions were compared between the two groups.Results The PFS of the observation group was longer than that of the control group(P＜0.05).The survival rate of the observation group was higher than that of the control group after 12 months of follow-up,and the differences were statistically significant(P＜0.05),but there was no significant difference in the survival rate between the two groups after 6 and 18 months of follow-up(P＞0.05).The clinical effective rate and disease control rate of the observation group were higher than those of the control group(P＜0.05).After treatment,the AFP level of the two groups was lower than that before treatment,and that of the observation group was lower than that of the control group(P＜0.05).The incidence of nausea and vomiting in the observation group was lower than that in the control group(P＜0.05),but there was no significant difference in the incidence of pain and fever between the two groups(P＞0.05).Conclusion Compared with traditional TACE,transcatheter arterial chemoembolization with pirarubicin-loaded microspheres combined with apatinib is more effective in the treatment of PLC,which can prolong the PFS of patients,improve the survival rate of patients,and at the same time,the gastrointestinal reaction is lighter.
Pirarubicin-loaded microspheresTranscatheter arterial chemoembolizationApatinibPrimary liver cancer
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维普
