首页|槐杞黄颗粒联合醋酸泼尼松治疗儿童原发性肾病综合征的效果及对凝血功能、免疫功能的影响

槐杞黄颗粒联合醋酸泼尼松治疗儿童原发性肾病综合征的效果及对凝血功能、免疫功能的影响

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目的 探究槐杞黄颗粒联合醋酸泼尼松治疗原发性肾病综合征(PNS)的效果及对凝血功能、免疫功能的影响.方法 将我院2020年4月-2022年4月收治的47例住院期间确诊为PNS患儿随机分为观察组(n=24)和对照组(n=23).对照组仅予以醋酸泼尼松治疗,观察组予以醋酸泼尼松联合槐杞黄颗粒治疗,比较两组治疗4周后尿蛋白/尿肌酐比值、血小板、血总胆固醇、血白蛋白、凝血功能(纤维蛋白原、D-二聚体、抗凝血酶Ⅲ)、免疫球蛋白(IgA、IgM、IgG)、淋巴细胞亚群计数指标(CD3+、CD3+CD4+、CD4+/CD8+)及不良反应发生情况.结果 两组治疗后白蛋白、IgG高于治疗前,且观察组高于对照组(P<0.05);两组治疗后血小板、尿蛋白/尿肌酐比值、纤维蛋白原低于治疗前,且观察组低于对照组(P<0.05);两组治疗后总胆固醇、D-二聚体、抗凝血酶原Ⅲ、IgA、IgM、CD3+、CD3+CD4+、CD4+/CD8+水平比较,差异无统计学意义(P>0.05).结论 槐杞黄颗粒联合醋酸泼尼松治疗能够在较短时间内降低PNS患儿尿蛋白水平,提升白蛋白,维持免疫球蛋白IgG正常水平,改善血小板和纤维蛋白原,从而改善患儿高凝状态,且安全性较高.
Effect of Huaiqihuang Granules Combined with Prednisone Acetate in the Treatment of Children with Primary Nephrotic Syndrome and its Influence on Coagulation Function and Immune Function
Objective To explore the effect of Huaiqihuang granules combined with prednisone acetate in the treatment of primary nephrotic syndrome(PNS)and its influence on coagulation function and immune function.Methods From April 2020 to April 2022,47 children diagnosed with PNS during hospitalization in our hospital were randomly divided into observation group(n=24)and control group(n=23).The control group was treated with prednisone acetate alone,The observation group was treated with prednisone acetate combined with Huaiqihuang granules.The urinary protein/urinary creatinine ratio,platelet,total cholesterol,albumin,coagulation function(fibrinogen,D-dimer,antithrombin Ⅲ),immunoglobulin(IgA,IgM,IgG),lymphocyte subsets count index(CD3+,CD3+CD4+,CD4+/CD8+)and adverse reactions were compared between the two groups after 4 weeks of treatment.Results After treatment,serum albumin and IgG in the two groups were higher than those before treatment,and those in the observation group were higher than those in the control group(P<0.05).After treatment,the platelet,urine protein/urine creatinine ratio and fibrinogen in the two groups were lower than those before treatment,and those in the observation group were lower than those in the control group(P<0.05).There was no significant difference in the levels of total cholesterol,D-dimer,antithrombin Ⅲ,IgA,IgM,CD3+,CD3+CD4+and CD4+/CD8+between the two groups after treatment(P>0.05).Conclusion Huaiqihuang granules combined with prednisone acetate can reduce the level of urinary protein in children with PNS in a short time,increase the level of albumin,maintain the normal level of immunoglobulin IgG,improve platelets and fibrinogen,so as to improve the hypercoagulable state of children,with higher safety.

Primary nephrotic syndromeHuaiqihuang granulesCoagulation functionImmune function

吴培、陈竹、李灵芝、肖尧侥

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电子科技大学医学院附属绵阳医院/绵阳市中心医院儿科,四川 绵阳 621000

肾病综合征 槐杞黄颗粒 凝血功能 免疫功能

湖北陈孝平科技发展基金会免疫性疾病研究槐杞黄专项(2020)

CXPJJH12000003-202022

2024

医学信息
国家卫生部信息化管理领导小组 中国电子学会中国医药信息学分会 陕西文博生物信息工程研究所

医学信息

影响因子:0.161
ISSN:1006-1959
年,卷(期):2024.37(1)
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