Clinical Efficacy of Endocrine Therapy in Patients with Negative Pathological Features After Radical Prostatectomy
Objective To investigate the effect of endocrine therapy in patients with pathological stage＜T3,lymph node negative,negative margin,negative vascular invasion and immediate postoperative PSA reduction＜0.1 ng/ml after localized high-risk radical prostatectomy.Methods A retrospective analysis of 90 patients with localized high-risk prostate cancer who underwent laparoscopic radical prostatectomy in our hospital from January 2016 to December 2022 and whose postoperative pathological features met pathological stage＜T3,negative lymph node,negative margin,negative vascular invasion,and PSA decreased to＜0.1 ng/ml immediately after surgery.According to different treatment options,they were divided into laparoscopic radical prostatectomy+endocrine therapy(RP+ADT)group and laparoscopic radical prostatectomy follow-up(RP)group,with 45 patients in each group.The total biochemical recurrence rate,1-year,2-year,3-year biochemical recurrence rate,PSA progression-free survival,and adverse reactions of endocrine therapy were compared between the two groups.Results There was no significant difference in the total biochemical recurrence rate,1-year,2-year,3-year biochemical recurrence rate and PSA progression-free survival between the two groups(P＞0.05).In the RP+ADT group,1 case had mild gross hematuria after endocrine therapy,and recovered after 1 month;13 cases had hot flashes,3 cases had hepatotoxicity(mild transaminase elevation),1 case had osteoporosis and 1 case had cerebral infarction.The number of adverse reactions of endocrine therapy was small and could not be statistically analyzed.Conclusion For patients with localized high-risk prostate cancer whose pathological features meet the pathological stage＜T3,lymph node negative,negative margin,negative vascular invasion and immediate postoperative PSA reduction to＜0.1 ng/ml,it is recommended to follow up for 3 years after surgery.After 3 years,follow-up treatment is determined according to the increase of PSA in patients.
国家科技期刊平台
NSTL
万方数据
维普
